Endometrial Receptivity Analysis (ERA)
Personalized molecular diagnostic testing that identifies your exact receptive window for embryo transfer, solving recurrent implantation failure.
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Understanding the Procedure & Clinical Approach
The Endometrial Receptivity Analysis (ERA) is a cutting-edge genetic diagnostic test that evaluates the receptivity of the uterine lining (endometrium) at the molecular level. While standard IVF assumes a universal implantation window, up to 25% of patients have a displaced receptive window (pre-receptive or post-receptive).
By analyzing the expression of 248 specific endometrial genes, ERA pinpoint accurately the optimal hour for embryo transfer, ensuring personalized embryo transfer (pET).
Step-by-Step Treatment Protocol
Mock Hormone Replacement Cycle
The patient undergoes a standardized estrogen and progesterone preparation cycle identical to an embryo transfer cycle.
Endometrial Sampling Biopsy
On the designated day (e.g., P+5), a minor, quick endometrial tissue sample is taken in the clinic.
NGS Genetic Expression Profiling
The RNA is sequenced to categorize the lining as Receptive, Pre-Receptive, or Post-Receptive.
Personalized Transfer Protocol
The subsequent Frozen Embryo Transfer is adjusted by adjusting progesterone exposure hours precisely to the patient’s personalized window.
Who is an Ideal Candidate?
- ✓ Patients with Recurrent Implantation Failure (2 or more failed transfers with good embryos)
- ✓ Patients with a limited number of precious blastocysts or euploid embryos
- ✓ Women with previous thin or irregular endometrial lining responses
- ✓ Couples wanting maximum certainty before embryo transfer
Frequently Asked Questions
Is the ERA biopsy painful?
The biopsy takes about 30 seconds and causes mild menstrual-like cramping. A mild analgesic can be taken beforehand for optimal comfort.
Does the ERA test need to be repeated?
No. Unless there is significant body weight fluctuation or surgical uterine intervention, the personalized window of implantation remains valid for multiple years.
Quick Treatment Facts
Timeline: 1 Diagnostic Mock Cycle
Hospital Stay: In-Clinic (10 Mins)
Location: Ramesh Hospitals, Ongole
Ready to discuss ERA Testing?
Take the first step with confidence. Book your consultation with Dr. Prathima Kamisetty at Komali Fertility Centre Ongole.